Potential Lubricating Mechanism of Hyaluronic Acid for a Reduction of Albumin-Mediated Friction in the Artificial Joint System

The average lifespan of artificial joints is 15–25 years, but it still too short for young and active patients. Human synovial albumin easily adsorbed on the surfaces joint materials has increased friction when subjected to conformational changes. Most studies have focused interaction between fluid components protein conformation not been modified, how reduce wear caused by denatured proteins. This study aimed investigate whether hyaluronic acid could provide lubrication albumin-mediated high was disrupted secondary structure albumin. Thermally processed human used as while testing, measurement conformation, adsorption, viscosity analysis were investigated. results demonstrated that adding fresh thermally solution 50% coefficient totally with 40 times more than alone, area twice. showed provided increasing mediated albumin, may a potential prolonging joints.